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正在implemente在线粒度分析d across many processing industries, thanks to its proven ability to change process control and deliver significant economic benefits in terms of higher throughput, lower energy consumption, reduced waste, and improved product quality. As manufacturers adopt on-line particle size analysis, the issue of how best to implement a successful project becomes highly relevant.
本文探讨了在线粒度尺寸的设计和实现的不同选项，强调了选择适合特定项目的实际益处。
Setting Realistic Expectations
Despite the fact that several on-line techniques are still relatively new, on-line laser diffraction particle size analysis is well-established across a range of industries. Early adopters of on-line particle size analysis have led the way in overcoming implementation problems. As a result, there is now a safe knowledge base encompassing virtually every type of application. Therefore, new users have options in terms of implementation strategy that ranges from procuring a sensor to handing the entire project over to the instrument supplier.
硬件选择
任何粒度尺寸项目的第一个也是最重要的一步是识别满足所需规范的硬件。要选择最佳解决方案，请考虑衡量过程的频率至关重要。例如，实时激光衍射粒度分析仪可以在一秒钟内测量完整的粒度分布，但在某些情况下，这不是严格要求的。
如果检测不重要或者即时沮丧the process has slow dynamics, then a lower measurement frequency can be sufficient. In such instances, a single sensor might be able to cover various points in the process, thus improving the potential benefit.
Process Interface Design
Analytical instrumentation, which is developed for constant use in the plant environment, must integrate and interface with the process. A major issue in particle size measurement is reliable, representative sampling because failures in this area are usually the main source of error in reported data. The simplest option would be to use in-line laser diffraction measurement, as this can be utilized wherever practicable. However in some situations, in highly concentrated streams for instance, the analyzer has to be installed on-line, on a discrete sampling loop.
Malvern Panalytical offers a consultancy service to deal with this aspect of the project and identifies an optimal solution through an on-site trial. Such services, in addition to validating the most suitable interface design, provide confidence that the technology will deliver to expectations.
自动化和集成
在最简单的情况下，连续粒度分析仪可包括较小的自动化，通过独立计算机运行，具有清洁的空气和功率，是唯一的额外要求。然而，对多元控制的趋势使支持软件和硬件的主要进步。
一个如此突出的开发一直是推出OPC架构，专门设计的标准化，使得更容易将一系列控制系统中的仪器组合在一起。多元控制系统的开发变得越来越容易，自动化硬件和相关软件领域的选项众多。
Validating the Solution
验证需求是某些行业的重要因素，特别是在制药行业，这些要求与工业不同。标准要求可能包括：
- Site acceptance testing
- 21CFR Part 11
- IQ / OQ测试和文档
- 工厂验收测试
此外，可能需要对供应公司的审计。
调试和控制优化
快速有效的调试非常重要，但同样重要的是确保最佳使用所产生的数据。如果目标是自动控制，那么主要目的是快速有效地关闭控制回路。为此，激光衍射连续粒度分析仪提供完整的粒度分布。换句话说，控制 - 无论是自动还是手动 - 都可以基于任何数量的参数，例如，低于5μm，3到30μm，或超过200μm，或参数的组合。在这里，选项取决于粒度分布的哪个特定元件，最佳地定义了产品的性能。
Conclusion
A successful project provides the desired outcome within the proposed timeframe. Key to achieving this objective is being realistic about how the project will transform operation and what it will involve in terms of expertise, time and money to realize these benefits. A major aspect of these considerations is how best to execute the project.
The development of on-line laser diffraction particle sizing has introduced a range of options as to how best to work with a supplier, when using the technology. Being practical about in-house strengths and limitations is important in choosing the most appropriate approach and to using the technology in the best possible way.
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This information has been sourced, reviewed and adapted from materials provided by Malvern Panalytical.
有关此来源的更多信息，请访问Malvern Panalytical。