Titrimetric Citric Acid Determination at Coca-Cola Services Belgium

可口可乐是世界领先的非酒精饮料生产国，该饮料是在大约1000个生产工厂中生产的。除了装瓶工厂外，该公司还设有许多技术中心，并在该全球管理质量保证（QA），并开发了新的包装和产品。

Coca-Cola executes many QA-activities, and among these one is dedicated to establishing the quality aspects of products that are bought from the local markets. Such quality attributes are examined to confirm whether the products conform to the internal specifications and meets the customers and consumers’ expectations. All of these activities are performed in European Quality Centers (EQC).

For over a decade, Coca-Cola has continued to be associated with Metrohm. Earlier in 2004, Coca-Cola visited the Mexican subsidiary and presented a new Metrohm titration system to the Belgian people. After listening to the excellent experiences of the Mexican associates, the company decided to establish a closer cooperation with Metrohm Belgium.

Requirements for a New System

各种饮料中的柠檬酸浓度和pH值是需要通过新系统测量的参数。由于必须检查大量产品，因此可口可乐服务实验室（该公司的比利时子公司）的工作量极高。理想的分析系统应提供精确，一致的结果，同时应具有高吞吐量和经营许多样品的必要能力，而无需任何操作员干预，这一点至关重要。

必须处理不同类型的样品，而无需始终对工作站进行物理调整。鉴于该大量样品的样品制备（移液）需要大量时间，并且更容易出现错误，因此可口可乐服务欢迎自动化系统的概念，该系统从一开始就提供了专业且可重复的样品制备。

完全自动化的滴定系统

The titration system is fully automated and includes two814 USB sample processorsfitted with two external titration vessels, two 800 Dosinos with Dosing Units, two 772 Pump Units, an808 Titrando使用两个测量输入，一个802搅拌器（螺旋螺旋螺旋air骨），805 dosimat和804 Ti支架（图1）。样品架都安装在两个设置上，这些架子能够处理多达127个小瓶，每个架子的体积为11毫升样品。由Dosino控制并配备了独特设计的针头的吸管管用于转移样品。该针还可以管理包含纸浆的样品（图2）。

图1。Julie Tilquin is the responsible lab technician for the fully automated Metrohm titration system.

图2。特殊设计的针头的特写，以吸入甚至果肉样品。

The Determination

The determination is automatically performed. Therefore, following the degassing process, the beverage samples are placed on the sample rack and the sample data table is filled with the suitable sample data. These are the only manual tasks involved.

10 mL of the sample is automatically pipetted into the external titration cell, where some additions of auxiliary solutions are added. Following electrode calibration, the citric acid titration is carried out. Pipetting, cleaning, quantifying, and titrating of the system are automatically carried out in a single run.

Data Evaluation

Metrohm的Tiamo™是一种经过验证的滴定软件，用于完全控制滴定系统。借助Tiamo™多版本，可以通过组织良好和直观的用户界面从任何办公桌上查看各种工作场所的结果。该数据库提供了控制结果，寻找结果并共同组装的所需工具。

快速过滤器可以通过无数确定来快速搜索。此外，控制图可快速概述结果的时间顺序。TIAMO™软件符合FDA法规21 CFR第11部分的要求。

Conclusion

Since February 2005, the European Quality Centre in Brussels has been using the Metrohm system and is quite happy with the results, because all its demands are fully met.

• 快速和节省时间的分析
• 高通量
• 出色的精度和可重复性
• 可靠的系统，可以在一夜之间提供无人值守的操作
• 如果需要，Metrohm的快速而有能力的支持

Metrohm’s fully automated, customized system can be effectively used to prepare and analyze large amounts of beverage samples. The samples’ citric acid concentration can be easily tracked from the office desk.

This information has been sourced, reviewed and adapted from materials provided by Metrohm AG.

有关此消息来源的更多信息，请访问Metrohm Ag。