Identifying Materials by FingerPrint

在过去的几年中，它已成为筛查药品领域中所有传入生产材料的典型实践。欧洲杯足球竞彩这种做法限制了产品责任和浪费。由于EDXRF方法没有大量的热样品，因此它适用于有机和无机材料测试。此外，作为一种同时检测所有元素（从NA到AM）的方法，EDXRF非常适合快速材料识别。

介绍

The Epsilon 3^X是一种高性能台式能量色散X射线荧光（EDXRF）光谱仪，完全能够识别材料。欧洲杯足球竞彩本文已经描述了这一点。

The examples considered in this article are common materials used in the manufacture of pharmaceutical products. The fingerprinting method is applicable to all materials including powders, liquids and solids. FingerPrint software is available for the Epsilon 3 andEpsilon 3^Xrange of XRF spectrometers.

Instrumentation

使用的仪器配有钼阳极管，六个过滤器，50 kV和1 mA发电机，氦气清洗设施（所有应用都不需要），一个旋转器，高分辨率硅漂移检测器和10位可移动样品改变者。

Sample Preparation

Loose powder standards and samples were simply placed into disposable P1 sample cups filled to an estimated depth of 1 cm.

方法开发

使用标准功能建立了理想的指纹条件：优化条件。测量时间为每个条件设置的150秒，导致总测量时间为300秒。指纹按钮被切换为选择指纹应用程序。

This one-time arrangement includes selecting from a range of distinguishing factors controlling the Chi²regression algorithm. Default settings are recommended for first-time use.

Create a Library - Measure Standards

使用指纹选项时，进行任何解释不是必不可少的。一组通用材料刚刚加载和测量。欧洲杯足球竞彩

XRF Intelligence - Capturing Subtle Differences

指纹软件使用高级统计算法来检查整个扫描。这包括背景配置文件和峰形之类的功能。

A main advantage is that fingerprinting is a fully automated method without the need for interpretation.

General Use Materials Library Spectra

With the scan viewing function, spectra from samples and standards can be viewed as seen in Figure 1. This step is not essential but demonstrates the resolving power of theEpsilon 3^X.

Figure 1.Example spectra from the reference library.

测量未知数

Unidentified samples were kept on the sample tray. Measurements were started once the corresponding sample positions were identified.

碳酸钾的新制剂被测量为未知。

Instant Identification - Results

The identification of the unknown is automatically conveyed. The unknown example was a match for potassium carbonate, as illustrated in Table 1.

表格1。候选列表扩展了视图。

Instant identification (candidate list)	Chi2*	确认**
碳酸钾	0.01	是的
Potassium bicarbonate	3.2	不
氯化铵	676936.10	不

* Statistically scoring candidates - lower Chi²values are better matches.
**最低的chi²values are considered a match.

结论

本文清楚地表明Epsilon 3^XXRF光谱仪可以用于快速指纹识别所有样品，包括原材料，赋形剂，试剂和最终产品。欧洲杯足球竞彩指纹识别和元素定量也可以以单个方法进行集成。

此信息已从Malvern Panalytical提供的材料中采购，审查和改编。欧洲杯足球竞彩

For more information on this source, please visitMalvern Analytical.