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自动化样品准备/LC系统从Thermo Fisher Scientific促进LC-MS/MS分析

Thermo Fisher Scientific,Inc。,服务科学领域的世界领导者,今天介绍了欧洲杯线上买球Thermo Scientific Prelude SPLC样品制备和液相色谱系统开发的目的是对复杂生物学矩阵中的靶化合物进行分析,以进行临床研究和法医毒理学实验室。

LC-MS/MS offers significant advantages in selectivity and quantitative accuracy over immunoassays and other analytical techniques, according to numerous published studies. However, Thermo Fisher Scientific “Voice of the Customer” surveys indicate that many clinical researchers consider the need for specialized mass spectrometry expertise a barrier to adopting this powerful technology.

“我们的意图是证明现在可以进行LC-MS/MS生物分析的情况很容易,” Heleto Fisher Marketing,Life Science Mass Spectromegery Marketing Gresising副总裁Ken Miller说。欧洲杯线上买球“随着临床研究社区越来越认识到LC-MS/MS的好处,我们设定了一个目标,使该技术比标准HPLC系统更容易访问。为此,我们设计了MS工作流的前端,强调健壮性,负担得起的拥有成本和更好的使用易用性。我们认为前奏性SPLC系统成功了。”

前奏性SPLC样品制备和液相色谱系统旨在与Thermo Scientific质谱仪(例如Thermo Scientific TSQ Vantage triple-stage quadrupole instrument。The TSQ Vantage system is known for its very high sensitivity and low noise, enabling quantitative analysis and positive identification of drugs, drug metabolites and steroids in biological samples.

前奏SPLC系统旨在通过自动化样品制备和增加质谱仪吞吐量来提高LC-MS/MS仪器的成本效益。自动化可以最大程度地减少手动样本准备程序中固有的可变性,同时还减少样本准备时间和精力。创新的Thermo Scientific Turboflow技术旨在消除样品基质干扰引起的问题,同时捕获感兴趣的分析物。这种样品清理水平可以通过减少离子抑制来增强MS定量分析。质谱仪离子源的污染也可以减少,从而最大程度地减少维护要求。

前奏性SPLC系统可以通过在内部内外实现此功能来降低研究实验室的运营成本,因为它具有两个高性能液相色谱(HPLC)分离的渠道,质谱仪时间范围的时间可以可以与单个通道LC系统相比,要降低。这通常转化为较高的样品吞吐量。

LC-MS/MS性能可以通过以1-2000 mL/min的流速为1-2000 mL/min的精确和可重现的低量梯度运行进一步增强,与标准的HPLC系统相比,这可以实现快速,高分辨率的分离。

Ease of use is enhanced by Thermo Scientific TraceFinder software, which provides a single, easy-to-learn interface for both the LC and MS functions. These include instrument control, data acquisition, data processing and reporting. Thermo Scientific Quick Start methods are designed to facilitate implementation of LC/MS for users who may not be mass spectrometry experts. Once a method is loaded, users can begin running samples with as few as six clicks of the mouse.

Prelude SPLC系统软件具有远程仪器监视和诊断功能,旨在减少对现场故障排除技能的需求。Thermo Scientific技术人员可以在线查明硬件问题。

Prelude SPLC系统是在ISO 13485认证的Thermo Fisher设施上制造的。ISO 13485是国际公认的质量管理标准。

For more information, visitwww.thermoscientific.com/prelude

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    Thermo Fisher科学。2019。自动化样品准备/LC系统从Thermo Fisher Scientific促进LC-MS/MS分析。Azom,2022年6月18日,https://www.wireless-io.com/news.aspx?newsid=35694。

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