A High-Performance Ruthenium-Based Catalyst for Production of Primary Amines

东京理工学院（Tokyo Tech）的研究人员开发了一种高性能可重复使用的基于氟芬氏菌的催化剂，用于生产原胺。它们的方法代表了开发有效催化剂的重大进步，该催化剂能够在轻度反应条件下选择性转化为原代胺。

Primary amines are extremely versatile building blocks that are used in the preparation of many kinds of dyes, detergents, pharmaceuticals and agricultural chemicals. So far, several methods have been developed to produce primary amines using catalysts containing ruthenium, cobalt and platinum, all of which require the addition of molecular hydrogen. Synthesis of primary amines by direct substitution of alcohols with ammonia has been a longstanding challenge.

Now, researchers at Tokyo Tech report a heterogeneous ruthenium-based catalyst (Ru-MgO/TiO₂）能够直接胺化酒精以产生幼胺，而无需引入氢气。他们表明该催化剂在低温下起作用，约为100°C。酒精的现成可用性和低成本的氨使该系统既具有成本效益又具有环境友好。

与以前的基于松伦的系统相比，Ru-Mgo/Tio₂achieved higher yields (up to 94%) of the desired primary amines. Reuse experiments showed that after base treatment, the catalyst could be reused three times without significant loss of activity.

他们的研究发表在化学科学欧洲杯线上买球，表明催化剂的MGO成分在通过从MGO到RU的电子捐赠来增强反应性方面起着重要作用。

The researchers point out that the new catalytic system could be applied to a variety of alcohols, and could serve as a design guide for other new heterogeneous catalysts.

In addition, Ru-MgO/TiO₂could provide an efficient synthetic route for the production of 2,5-bis(aminomethyl)furan (BAMF), an attractive compound used as a hardener for epoxy resins, which are used in many types of coatings and adhesives. Using biomass-derived 2,5-bis(hydroxymethyl)furan (BHMF) as a substrate, the study showed the desired BAMF was obtained at 86% yield, outperforming previous systems.

Source:https://www.titech.ac.jp/english/