Chemical Insights About Ceramic may Help Develop Novel Bone-Replacement Biomaterial

您在明年的某个时候折断骨头的机会接近4%。如果您不幸的是需要更换骨骼,则可能基于金属部分。不幸的是,金属零件有时会随着时间的流逝而有毒,并且不会帮助您的原始骨骼再生。磷酸钙陶瓷 - 替代骨矿物羟基磷灰石 - 原则上是常规金属的理想替代品,因为骨骼最终可以替代陶瓷和再生。然而,这种陶瓷在医疗环境中的应用受到了对植入后骨骼的吸收率和替换率的控制率的限制。

现在,在最近发表的高级材料科学技术的研究中,TMDU和合作伙伴的研究人员研究欧洲杯线上买球了含钙离子的磷酸酯陶瓷碳链长度的影响,该含钙离子对钙磷酸酶介导的羟基磷欧洲杯足球竞彩灰石的转化速率哪个出现在我们的骨头中。这项工作将有助于将骨骼再生研究从实验室转移到医疗用途。

"Medical professionals have long sought a means of healing bone fractures without using implanted medical devices, but the underlying science that can make this dream a reality isn't yet fully elaborated,"解释说,首席作者田纪洋子。“我们对陶瓷酯烷基链长度对羟基磷灰石形成的影响的仔细分析,在模拟的体液中可能有助于开发新型的骨替代生物材料。”

The researchers report two main findings. First, most of the studied ceramics underwent chemical transformations into particulate or fibrous hydroxyapatite within a few days. Second, smaller alkyl groups facilitated faster chemical reactions than larger alkyl groups. Because the rate-limiting step of hydroxyapatite formation is dissolution of the ceramic, the greater solubility imparted by smaller alkyl groups sped up production of hydroxyapatite. Such knowledge gives a means of tailoring the speed of bone regrowth.

“我们现在有关于如何从磷酸钙陶瓷量身定制羟基磷灰石生长速率的特定化学知识,”says Yokoi.“我们预计,这种知识对于替补席研究人员和医生将很有用,可以在医学上相关的条件下更有效地为调整骨改革率进行协作。”

The results of this study are important for healing bone fractures after surgery. By using chemical insights to optimize the rate of bone reformation after implantation of calcium phosphate ceramics, patient outcomes will improve, and returns to the hospital years later for further repairs will be minimized.

The article,"Transformation behaviour of salts composed of calcium ions and phosphate esters with different linear alkyl chain structures in a simulated body fluid modified with alkaline phosphatase,“发表在Science and Technology of Advanced Materials在:doi:10.1080/14686996.2022.2074801

Source:https://www.tmd.ac.jp/english/

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