In an article recently published in the open-access journal科学报告，研究人员讨论了使用生物活性玻璃的丙烯酸树脂制备和表征。
学习：用生物活性玻璃制备和表征丙烯酸树脂。Image Credit: Cat Us/Shutterstock.com
Background
Although new substitutes have emerged, acrylic materials are still most frequently utilized in prosthetic dentistry to create removable dentures. Unfortunately, acrylic resins have significant drawbacks in addition to their many benefits, such as the restricted saliva flow in the denture base area. The factors that may contribute to dental alterations in the remaining teeth include wearing dentures, eating, and the consequent reduction in saliva flow in the region of the remaining teeth. As a result, acrylic resins ought to be altered to boost their bioactivity.
包括氧化钛和银在内的不同种类的纳米颗粒的掺入是一种用于改变丙烯酸聚合物并产生生物活性材料的欧洲杯猜球平台方法之一。欧洲杯足球竞彩包括各种类型的药物是另一种方式。除这些方法外，还可以通过应用各种生物活性玻璃来修改丙烯酸材料。欧洲杯足球竞彩
这种方法已经广泛用于正畸粘合剂，复合填充物和玻璃离子体水泥。到目前为止，这些眼镜已成功地用于牙膏，复合材料和玻璃离子体水泥或生物素。氟离子可以通过添加CAF从玻璃中释放2。但是，CAF太多2会导致晶相自发结晶。氯磷灰石将从牙齿的角度在水存在下转变为羟基磷灰石（HA）。这些实验中使用的一种类型的氟玻璃是生物素F。
样品制备和测试方案。图片来源：Raszewski，Z等人，科学报告
关于the Study
In this study, the authors used various varieties of glasses to create a bioactive acrylic material. 10% of four different types of powdered glasses were combined with commercially available polymerized acrylic resin, and subsequently, the mixture was dried. The samples' sorption capacity, flexural strength, and solubility were evaluated in accordance with ISO 20795-1:2013. A total of 60 samples were utilized in the experiments. Elution of the materials was undertaken for 0, 1, 28, and 42 days after they were immersed in artificial saliva with a pH of 4 to 7.
该团队使用电感耦合等离子体原子发射光谱法来评估样品以找到Ca，P和Si离子，而离子色谱法则用于查找F离子。在达到标准标准时，用玻璃修饰后产生的材料的抗压强度低于纯甲基丙烯酸欧洲杯足球竞彩甲酯。两种玻璃表现出的溶解度值高于ISO标准指定的值。在人造唾液中42天后，生物素C和S53P4分别释放了P，CA和SI离子。在28天和42天的酸性条件下，用10％生物蛋白C处理的S53P4玻璃和丙烯酸树脂可能是CA和P离子的有用来源。
研究人员创建了一种丙烯酸物质，该物质释放了钙，磷和氟离子，并具有生物活活率甲基丙烯酸酯。它可以基于复合材料中存在的甲基丙烯酸酯树脂的类似系统产生具有生物活性品质的材料。欧洲杯足球竞彩
Observations
The results showed that all samples with bioactive glasses only had a 10% drop in flexural strength. The addition of particular kinds of glasses to poly (methyl) g glass S53P4 and Biomin C showed the maximum flexural strength. In comparison to the data obtained after 24 hours, a greater decrease in flexural strength was seen after 30 days. The minimum ISO standard requirement for denture base materials was 65 MPa, and all results were higher than this value. The acrylic system could release ions into the reaction environment when bioactive glass was added, which acted as a source of raw materials for the formation of HA. The type of glass being used affected how quickly ions were released.
After being altered using bioactive glass, the acrylic material created in this study met the ISO 20795-1: 2013 standard for sorption and flexural strength. The calcium and silicon phosphor ions in the acrylic resin made with a 10% addition of various active glasses could be released. The release of fluorine ions in an acidic environment was extremely dynamic in the case of Biomin F glass as it occurred within the first 24 h. Ions were released progressively over a 42-day period in a neutral atmosphere.
在42天的酸性条件下，用10％生物素C和S53P4玻璃处理的丙烯酸树脂是钙阳离子和磷酸盐阴离子的有用来源。与未修饰的树脂相比，丙烯酸树脂显示出较低的弯曲强度，并添加了四个不同的生物活性玻璃。含有生物蛋白F的样品的弯曲强度为78.05±5.91 MPa，与含有纯PMMA的样品相当。去离子水或合成盐水中的丙烯酸聚合物吸附的范围为17.5±0.88至27.25±1.04μg/mm3。The sorption value for the reference material Superacryl Plus was 10 μg/mm3,and the sorption value for the Biomin F sample was 9.48 ± 0.81 μg/mm3。
Conclusions
In conclusion, this study discussed the development of composite materials made by combining PMMA with four distinct kinds of glasses. The four varieties of glasses gradually hydrolyzed under the action of water-released ions into the environment.
该小组观察到，任何丙烯酸材料的吸附和溶解度都受到其化学结构（例如存在不同离子的存在）的极大影响。在酸性pH值下，离子释放得更快。在pH 7时，由于形成等效盐而释放了更多的磷酸盐和硅酸盐阴离子。在pH 4处42天后，含有S53P4玻璃的样品产生了24.05±3.61、2.43±0.36和3.02±0.21 mg/l的PO43-，CA2+和Sio42-， 分别。在pH 4时，氟离子的最初24小时释放为7.05±1.06 mg/l。
参考
Raszewski，Z.，Chojnacka，K.，Mikulewicz，M.，等。用生物活性玻璃制备和表征丙烯酸树脂。科学报告，12，16624（2022）。https://www.nature.com/欧洲杯猜球平台articles/s41598-022-20840-1
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