改善了使用纳米线涂料对钛植入物的接受

阿肯色大学研究人员发现了一种简单，廉价的方法，可以在生物相容性钛表面上产生纳米线涂层，该涂层可用于创建更有效的髋关节置换，牙齿重建和血管置于牙齿置换的表面。此外，可以使用紫外线和水或使用乙醇轻松地对材料进行灭菌，从而使其在医院环境和肉类处理植物中有用。

Wenjun Dong，Tierui Zhang，Lisa Cooney，Hong Wang，Yanbin Li，Andrew Cogbill，Andrew Cogbill，Vijay Varadan和Arkansas大学的Z. Ryan Tian，新墨西哥大学的Ying-Bing Jiang和Arkansasas of Arkansasassasassasassasassasassasassasasassasasassasasassasasasassasasasasassasasassasasasasassasasasasassasasasassasasasasasassasasasasasassasasasassasasasasassasasasasassasasasasasasasin of Arkansasassasassasasassasasassasasassasasassasasassasasassasasassasasasassasasasasasasin of Arkanua Epstein对于医学科学，在即将发表欧洲杯线上买球的《材料化学杂志》上报告了他们的发现。欧洲杯足球竞彩

The researchers used an alkali and heat to create titanium oxide-based ceramic nanowires that coat the surface of a titanium medical device.

J. Ryan Tian说：“我们可以通过改变反应中的时间，温度和碱浓度来控制纳米线支架内的长度，高度，孔口和孔的体积。”威廉·富布赖特艺术与科学学院。欧洲杯线上买球“此过程也非常可持续，”仅要求在加热过程后用可重复使用的水冲洗设备。

重建骨手术（例如髋关节置换）使用钛植入物。但是，肌肉组织可能无法很好地遵循钛的光滑表面，从而导致植入物在十年左右的时间后失败，并要求患者进行第二次手术。

Tian and his colleagues created a nanowire-coated joint and placed it in mice. After four weeks, the researchers found that tissue had adhered to the joint.
“We saw beautiful tissue growth – lots of muscle fibers,” Tian said. “We’ve added one more function to the currently-in-use titanium implant.”

Because the researchers can control the size and shape of the pores in the nanowire scaffold, the material also could be coated onto stents used in patients with coronary artery disease and in potential stroke victims. Conventional stents sometimes become reclogged with fat after implantation. The most recent stent used to address this problem, called the drug-eluting stent, consists of a polymer coating mixed with the drugs, but the coating may be vulnerable to biodegradation, and may not function for long. The nanowire coating without the degradation problem could be used to carry drugs that would help keep the arteries clear over a long period of time.

“This drug release could be applied to the angioplasty catheter’s surface,” Tian said.

In addition to these biomedical applications, the nanofiber scaffold has a property that may make it useful in both hospitals and food processing plants: The material, when rinsed in water and exposed to ultraviolet light, kills more than 99 percent of bacteria on its surface. This effect occurs because photons from the light cause a charge separation on the material, splitting water molecules into free radicals that destroy the bacteria. Alternatively, immersion in 70 percent ethanol completely sterilizes the material, allowing growth of cells/tissues in the laboratory prior to implantation.

This property could prove extremely useful in bacteria-prone environments, performing such functions as sterilizing on-site surgery hospitals used during military actions or cleaning surfaces in meat-processing plants.

“You could just use water to rinse and UV light to sterilize surfaces,” Tian said.
The researchers have applied for a provisional patent for the multifunctional nanowire bioscaffolds on titanium or titanium-containing alloys such as Nitinol.